biliary intraepithelial neoplasia (bilin) in primary sclerosing cholangitis: the first report from iran
نویسندگان
چکیده
conclusions this study showed that the frequency of bilin was low among iranian patients with psc. high bilirubin and ca19-9 can be predictors of the development of bile duct epithelial changes in patients with psc. background primary sclerosing cholangitis (psc) as one of the most common chronic cholestatic liver diseases is a main predisposing factor for the development of cholangiocarcinoma (cca). biliary intraepithelial neoplasia (bilin) is defined as precancerous bile duct epithelial changes, which can be eventually led to cholangiocarcinoma. there are very few studies about the frequency of bilin in the patients with psc and its correlation with paraclinical findings. methods during two years (2014 - 15) of investigation, 80 explanted livers with the confirmed diagnosis of psc were studied through precise inspection and thorough sectioning of the explanted livers. these findings were correlated with paraclinical findings to identify any predictor of these neoplastic epithelial changes. results during the study period of 2 years, among 80 livers with confirmed diagnosis of psc, there were 43 cases with different types of metaplasia. the frequency of epithelial changes was as below: 29 (35%) for pyloric metaplasia, 9 (10.8%) for mucinous metaplasia, 3 (3.6%) for intestinal metaplasia, 1 (1.2%) for osteoid metaplasia, and 1 (1.2%) for squamous metaplasia. there was no epithelial dysplasia in the study sample; however, according to the most recent reports, mucinous metaplasia is considered as bilin 1; therefore, there would be 9 cases of bilin i. there has been no statistically significant difference between psc cases and those with bilin in demographic variables, except for bilirubin and ca19-9 which were higher in the psc cases with bilin. objectives in this study, we tried to find the frequency of bilin in the patients with psc and correlate its presence with clinicopathologic factors.
منابع مشابه
Biliary Intraepithelial Neoplasia (BilIN) in Primary Sclerosing Cholangitis: The First Report from Iran
BACKGROUND Primary sclerosing cholangitis (PSC) as one of the most common chronic cholestatic liver diseases is a main predisposing factor for the development of cholangiocarcinoma (CCA). Biliary intraepithelial neoplasia (BilIN) is defined as precancerous bile duct epithelial changes, which can be eventually led to cholangiocarcinoma. There are very few studies about the frequency of BilIN in ...
متن کاملPrimary sclerosing cholangitis and primary biliary cirrhosis.
Preview Although primary sclerosing cholangitis occurs most often in middle-aged or younger men and primary biliary cirrhosis in middle-aged or older women, the diseases have some traits in common-unfortunate ones. In both diseases, the cause is unknown, and liver transplantation is the only known effective therapy for advanced cases. Dr Fennerty discusses trials of medical treatments used in a...
متن کاملOverlapping of Primary Biliary Cirrhosis and Small Duct Primary Sclerosing Cholangitis: First Case Report
Primary biliary cirrhosis (PBC) and primary sclerosing cholangitis (PSC) are both autoimmune cholestatic liver disease and the association of these two conditions in the same patient is very rare. We report the case of a female patient presenting with a cholestatic liver disease and a panel of autoantibodies specific for PBC, including antibodies to mitochondrial E2-pyruvate dehydrogenase, gp-2...
متن کاملCurrent management of primary biliary cirrhosis and primary sclerosing cholangitis.
Primary biliary cirrhosis (PBC) is a chronic, cholestatic autoimmune liver disease characterized by inflammation and progressive destruction of interlobular bile ducts, ultimately leading to biliary cirrhosis. Population based studies have estimated the incidence of PBC as 19.1–251/ 1 000 000 in the general population [1,2]. The etiology of PBC is attributed to autoimmunity mainly due to the as...
متن کاملMedical treatment of primary biliary cirrhosis and primary sclerosing cholangitis.
Treatment of primary biliary cirrhosis (PBC) and primary sclerosing cholangitis (PSC) with ursodeoxycholic acid (UDCA) has been in common use since 1985. In PBC, treatment with UDCA improves laboratory data, liver histology, enables a longer transplantation-free interval and prolongs disease survival. Because UDCA is unable to cure the disease newer drugs or combination therapies are still need...
متن کاملمنابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
hepatitis monthlyجلد ۱۶، شماره ۱۲، صفحات ۰-۰
میزبانی شده توسط پلتفرم ابری doprax.com
copyright © 2015-2023